Publications

Full List of Publications in PubMed

Publications by Year

2024

Articles

  1. Cadinu P, Sivanathan KN, Misra A, Xu RJ, Mangani D, Yang E, Rone JM, Tooley K, Kye YC, Bod L, Geistlinger L, Lee T, Mertens RT, Ono N, Wang G, Sanmarco L, Quintana FJ, Anderson AC, Kuchroo VK, Moffitt JR, Nowarski R. Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling. Cell. 2024 Apr 11;187(8):2010-2028.e30. doi: 10.1016/j.cell.2024.03.013. PMID: 38569542. PMC11017707.
  2. Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao CC, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SEJ, Antel J, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ. Disease-associated astrocyte epigenetic memory promotes CNS pathology. bioRxiv [Preprint]. 2024 Jan 5:2024.01.04.574196. doi: 10.1101/2024.01.04.574196. Update in: Nature. 2024 Mar;627(8005):865-872. PMID: 38260616. PMC10802318.
  3. Rone JM, Faust Akl C, Quintana FJ. Astrocyte control of brain metastasis. Dev Cell. 2024 Mar 11;59(5):559-560. doi: 10.1016/j.devcel.2024.02.004. PMID: 38471436.
  4. Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao C, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SEJ, Antel JP, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ. Disease-associated astrocyte epigenetic memory promotes CNS pathology. Nature. 2024 Mar;627(8005):865-872. doi: 10.1038/s41586-024-07187-5. PMID: 38509377. PMC11016191.
  5. Linnerbauer M, Lößlein L, Vandrey O, Peter A, Han Y, Tsaktanis T, Wogram E, Needhamsen M, Kular L, Nagel L, Zissler J, Andert M, Meszaros L, Hanspach J, Zuber F, Naumann UJ, Diebold M, Wheeler MA, Beyer T, Nirschl L, Cirac A, Laun FB, Günther C, Winkler J, Bäuerle T, Jagodic M, Hemmer B, Prinz M, Quintana FJ, Rothhammer V. The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology. Nat Immunol. 2024 Mar;25(3):432-447. doi: 10.1038/s41590-024-01756-6. PMID: 38409259. PMC10907300.
  6. Ambrosio LF, Volpini X, Quiroz JN, Brugo MB, Knubel CP, Herrera MR, Fozzatti L, Avila Pacheco J, Clish CB, Takenaka MC, Beloscar J, Theumer MG, Quintana FJ, Perez AR, Motrán CC. Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease. Front
    Immunol. 2024 Jan 12;14:1267641. doi: 10.3389/fimmu.2023.1267641. PMID: 38283348. PMC10811785.

Reviews

  1. Kenison JE*, Stevens NA*, Quintana FJ. Therapeutic induction of antigen-specific immune tolerance. Nat Rev Immunol. 2024 May;24(5):338-357. PMID: 38086932. PMC11145724.

2023

Articles

  1. Wheeler MA*, Clark IC*, Lee HG*, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science. 2023 Mar 10;379(6636):1023-1030. doi: 10.1126/science.abq4822. PMID: 36893254. PMC10066924.
  2. Clark IC*, Wheeler MA*, Lee HG, Li Z, Sanmarco LM, Thaploo S, Polonio CM, Shin SW, Scalisi G, Henry AR, Rone JM, Giovannoni F, Charabati M, Akl CF, Aleman DM, Zandee SEJ, Prat A, Douek DC, Boritz EA, Quintana FJ, Abate AR. Identification of astrocyte regulators by nucleic acid cytometry. Nature. 2023 Feb;614(7947):326-333. doi: 10.1038/s41586-022-05613-0. PMID: 36599367. PMC9980163.
  3. Clark IC, Mudvari P, Thaploo S, Smith S, Abu-Laban M, Hamouda M, Theberge M, Shah S, Ko SH, Pérez L, Bunis DG, Lee JS, Kilam D, Zakaria S, Choi S, Darko S, Henry AR, Wheeler MA, Hoh R, Butrus S, Deeks SG, Quintana FJ, Douek DC, Abate AR*, Boritz EA*. HIV silencing and cell survival signatures in infected T cell reservoirs. Nature. 2023 Feb;614(7947):318-325. doi: 10.1038/s41586-022-05556-6. PMID: 36599978. PMC9908556.
  4. Sanmarco LM, Rone JM, Polonio CM, Fernandez Lahore G, Giovannoni F, Ferrara K, Gutierrez-Vazquez C, Li N, Sokolovska A, Plasencia A, Faust Akl C, Nanda P, Heck ES, Li Z, Lee HG, Chao CC, Rejano-Gordillo CM, Fonseca-Castro PH, Illouz T, Linnerbauer M, Kenison JE, Barilla RM, Farrenkopf D, Stevens NA, Piester G, Chung EN, Dailey L, Kuchroo VK, Hava D, Wheeler MA, Clish C, Nowarski R, Balsa E, Lora JM, Quintana FJ. Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells. Nature. 2023 Aug;620(7975):881-889. doi: 10.1038/s41586-023-06409-6. PMID: 37558878. PMC10725186.
  5. Bod L, Kye YC, Shi J, Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, Zaghouani S, Christian E, Delorey TM, Mohib K, Xiao S, Slingerland N, Giuliano CJ, Ashenberg O, Li Z, Rothstein DM, Fisher DE, Rozenblatt-Rosen O, Sharpe AH, Quintana FJ, Apetoh L, Regev A, Kuchroo VK. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023 Jul;619(7969):348-356. doi: 10.1038/s41586-023-06231-0. PMID: 37344597. PMC10795478.
  6. Tsaktanis T, Linnerbauer M, Lößlein L, Farrenkopf D, Vandrey O, Peter A, Cirac A, Beyer T, Nirschl L, Grummel V, Mühlau M, Bussas M, Hemmer B, Quintana FJ, Rothhammer V. Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing-remitting multiple sclerosis. Brain Commun. 2023 Jul 25;5(4):fcad206. doi: 10.1093/braincomms/fcad206. PMID: 37564830. PMC10411318.
  7. Linnerbauer M, Beyer T, Nirschl L, Farrenkopf D, Lößlein L, Vandrey O, Peter A, Tsaktanis T, Kebir H, Laplaud D, Oellinger R, Engleitner T, Alvarez JI, Rad R, Korn T, Hemmer B, Quintana FJ, Rothhammer V. PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation. Nat Commun. 2023 Sep 9;14(1):5555. doi: 10.1038/s41467-023-40982-8. PMID: 37689786. PMC10492803.

Reviews

  1. Kenison JE*, Stevens NA*, Quintana FJ. Therapeutic induction of antigen-specific immune tolerance. Nat Rev Immunol. 2024 May;24(5):338-357. PMID: 38086932. PMC11145724.
  2. Lee HG, Lee JH, Flausino LEF, Quintana FJ, Neuroinflammation: An astrocyte perspective. Sci.Transl. Med. 2023 Nov 8;15(721):eadi7828. DOI:10.1126/scitranslmed.adi7828. PMID: 37939162.
  3. Charabati M, Wheeler MA, Weiner HL, Quintana FJ. Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting. Cell. 2023 Mar 30;186(7):1309-1327. doi: 10.1016/j.cell.2023.03.008. PMID: 37001498. PMC10119687.
  4. Wheeler MA, Quintana FJ. Astrocytes on steroids binge on synapses to cope with stress. Immunity. 2023 Sep 12;56(9):1983-1985. doi: 10.1016/j.immuni.2023.08.013. PMID: 37703827. PMC10564114.
  5. Silverberg JI, Boguniewicz M, Quintana FJ, Clark RA, Gross L, Hirano I, Tallman AM, Brown PM, Fredericks D, Rubenstein DS, McHale KA. Tapinarof Validates the Aryl Hydrocarbon Receptor as a Therapeutic Target: A Clinical Review. J Allergy Clin Immunol. 2023 Dec 27:S0091-6749(23)02547-2. doi: 10.1016/j.jaci.2023.12.013. PMID: 38154665.

2022

Articles

  1. Quintana FJ, Pozo D. Editorial: Nanoparticle-Mediated Signaling Rewiring and Reprogramming of Immune Responses. Front Immunol. 2022 May 12;13:927733. PMID: 35634330.
  2. Couturier CP, Nadaf J, Li Z, Baig S, Riva G, Le P, Kloosterman DJ, Monlong J, Nkili Meyong A, Allache R, Degenhard T, Al-Rashid M, Guiot MC, Bourque G, Ragoussis J, Akkari L, Quintana FJ, Petrecca K. Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells. Neuro Oncol. 2022 Apr 13. PMID: 35416251.
  3. Linnerbauer M, Lößlein L, Vandrey O, Tsaktanis T, Beer A, Naumann UJ, Panier F, Beyer T, Nirschl L, Kuramatsu JB, Winkler J, Quintana FJ, Rothhammer V. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation. JCI Insight. 2022 Apr 8;7(7):e154824. PMID: 35393953.
  4. Jaronen M, Wheeler MA, Quintana FJ. Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish. STAR Protoc. 2022 Jan 28;3(1):101134. PMID: 35128477.
  5. Gutiérrez-Vázquez C, Quintana FJ. Protocol for in vitro analysis of pro-inflammatory and metabolic functions of cultured primary murine astrocytes. STAR Protoc. 2021 Dec 15;3(1):101033. doi: 10.1016/j.xpro.2021.101033. PMID: 34977679. PMC8686069.
  6. Sanmarco LM, Chao CC, Wang YC, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 Nov;611(7937):801-809. doi: 10.1038/s41586-022-05308-6. PMID: 36266581. PMC9898826.
  7. Charabati M, Grasmuck C, Ghannam S, Bourbonnière L, Fournier AP, Lécuyer MA, Tastet O, Kebir H, Rébillard RM, Hoornaert C, Gowing E, Larouche S, Fortin O, Pittet C, Filali-Mouhim A, Lahav B, Moumdjian R, Bouthillier A, Girard M, Duquette P, Cayrol R, Peelen E, Quintana FJ, Antel JP, Flügel A, Larochelle C, Arbour N, Zandee S, Prat A. DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation. Sci Transl Med. 2022 Jan 5;14(626):eabj0473. doi: 10.1126/scitranslmed.abj0473. PMID: 34985970.
  8. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis. iScience. 2022 Aug 24;25(9):105004. doi: 10.1016/j.isci.2022.105004. PMID: 36093065. PMC9460814.
  9. Alaamery M, Alghamdi J, Massadeh S, Alsawaji M, Aljawini N, Albesher N, Alghamdi B, Almutairi M, Hejaili F, Alfadhel M, Baz B, Almuzzaini B, Almutairi AF, Abdullah M, Quintana FJ, Sayyari A. Analysis of chronic kidney disease patients by targeted next-generation sequencing identifies novel variants in kidney-related genes. Front Genet. 2022 Aug 11;13:886038. doi: 10.3389/fgene.2022.886038. PMID: 36035137. PMC9407681.
  10. Muñoz Ú, Sebal C, Escudero E, Urcelay E, Arroyo R, García-Martínez MA, Quintana FJ, Álvarez-Lafuente R, Sádaba MC. Serum levels of IgM to phosphatidylcholine predict the response of multiple sclerosis patients to natalizumab or IFN-β. Sci Rep. 2022 Aug 3;12(1):13357. doi: 10.1038/s41598-022-16218-y. PMID: 35922641. PMC9349316.

Reviews

  1. Olude MA, Mouihate A, Mustapha OA, Farina C, Quintana FJ, Olopade JO. Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective. Front Immunol. 2022 May 30;13:795089. PMID: 35707531.
  2. Lee HG, Wheeler MA, Quintana FJ. Function and therapeutic value of astrocytes in neurological diseases. Nat Rev Drug Discov. 2022 May;21(5):339-358. PMID: 35173313.
  3. Andersen, B.M., Quintana, F.J. Neuro-immune crosstalk in drug-resistant epilepsy. Nat Neurosci (2022). PMID: 35739272
  4. Rodríguez Murúa S, Farez MF, Quintana FJ. The Immune Response in Multiple Sclerosis. Annu Rev Pathol. 2022 Jan 24;17:121-139. doi: 10.1146/annurev-pathol-052920-040318. PMID: 34606377.

2021

Articles

  1. Giovannoni F*, Li Z*, Remes-Lenicov F, Dávola ME, Elizalde M, Paletta A, Ashkar AA, Mossman KL, Dugour AV, Figueroa JM, Barquero AA, Ceballos A, Garcia CC, Quintana FJ. AHR signaling is induced by infection with coronaviruses. Nat Commun. 2021 Aug;12:5148. PMID: 34446714.
  2. Scott BM*, Gutiérrez-Vázquez C*, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A, Hewson P, Cox LM, O’Brien M, Chen SK, Moraes-Vieira PM, Chang BSW, Peisajovich SG, Quintana FJ. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021 Jul;27(7):1212-1222. PMID: 34183837
  3. Friedrich M*, Sankowski R*, Bunse L*, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg Anna, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M*, Platten M*. Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nat Cancer. 2021 Jul;2, 723–740. DOI: 10.1038/s43018-021-00201-z
  4. Kenison JE, Wang Z, Yang K, Snyder M, Quintana FJ, Sherr DH. The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation. Proceedings of the National Academy of Sciences. May 11, 2021 118 (19) e2012692118. DOI: 10.1073/pnas.2012692118
  5. Levy O*, Rothhammer V*, Mascanfroni I*, Tong Z, Kuai R, De Biasio M, Wang Q, Majid T, Perrault C, Yeste A, Kenison JE, Safaee H, Musabeyezu J, Heinelt M, Milton Y, Kuang H, Lan H, Siders W, Multon MC, Rothblatt J, Massadeh S, Alaamery M, Alhasan AH, Quintana FJ, Karp JM. A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 May;99(5):663-671. PMID: 33398468.

  6. Clark IC*, Gutiérrez-Vázquez C*, Wheeler MA*, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Polonio CM, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, de Lima KA, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 Apr 23;372(6540):eabf1230. PMID: 33888612. PMC8157482

  7. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proceedings of the National Academy of Sciences. 2021 March 118 (12) e2017719118. DOI: 10.1073/pnas.2017719118
  8. Rothhammer V, Kenison JE, Li Z, Tjon E, Takenaka MC, Chao CC, de Lima KA, Borucki DM, Kaye J, Quintana FJ. Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS. Neurol Neuroimmunol Neuroinflamm. Mar 2021, 8 (2) e946. DOI: 10.1212/NXI.0000000000000946
  9. Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm Mar 2021, 8 (2) e933; DOI: 10.1212/NXI.0000000000000933

  10. Sanmarco LM*, Wheeler MA*, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes. Nature. 2021 Feb;590(7846):473-9. PMID: 33408417. PMC8039910.

  11. Gutiérrez-Vázquez C, Quintana FJ. Protocol for in vitro analysis of pro-inflammatory and metabolic functions of cultured primary murine astrocytes. STAR Protoc. 2021 Dec 15;3(1):101033. doi: 10.1016/j.xpro.2021.101033. PMID: 34977679. PMC8686069.

  12. Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V. The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Jul 23;8(5):e1043. doi: 10.1212/NXI.0000000000001043. PMID: 34301821. PMC8312279.

Reviews

  1. Andersen BM*, Faust Akl C*, Wheeler MA, Chiocca EA, Reardon DA, Quintana FJ. Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 Sep 28 (in press). PMID: 34584243.
  2. Tuzlak S*, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F*, Korn T*, Becher B*. Repositioning T H cell polarization from single cytokines to complex help. Nat Immunol. 2021 Oct;22(10):1210-1217. PMID: 34545250.
  3. Sanmarco LM*, Polonio CM*, Wheeler MA*, Quintana FJ. Functional immune cell-astrocyte interactions. J Exp Med. 2021 Sep 6;218(9):e20202715. PMID: 34292315
  4. Alaamery M, Albesher N, Aljawini N, Alsuwailm M, Massadeh S, Wheeler MA, Chao CC, Quintana FJ. Role of sphingolipid metabolism in neurodegeneration. J Neurochem. 2021 Jul;158(1):25-35. PMID: 32402091.
  5. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling. Curr Opin Immunol. 2021 Jun;70:33-39. PMID: 33607496.
  6. Prinz M, Masuda T, Wheeler MA, Quintana FJ. Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. Annu Rev Immunol. 2021 Apr 26;39:251-277. PMID: 33556248.
  7. Torti MF*, Giovannoni F*, FJ Quintana†, García CC†. The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity. Front Immunol. 2021 Mar 5;12:624293. PMID: 33746961.
  8. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. The aryl hydrocarbon receptor and the gut-brain axis. Cell Mol Immunol. 2021 Feb;18(2):259-268. PMID: 33408340.
  9. Rodríguez Murúa S, Farez MF, Quintana FJ. The Immune Response in Multiple Sclerosis. Annu Rev Pathol. 2022 Jan 24;17:121-139. doi: 10.1146/annurev-pathol-052920-040318. PMID: 34606377.

2020

Articles

  1. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. PMID: 32051591. PMC8049843.
  2. Gevaert O, Nabian M, Bakr S, Everaert C, Shinde J, Manukyan A, Liefeld T, Tabor T, Xu J, Lupberger J, Haas BJ, Baumert TF, Hernaez M, Reich M, Quintana FJ, Uhlmann EJ, Krichevsky AM, Mesirov JP, Carey V, Pochet N. Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes. JCO Clin Cancer Inform. 2020 May;4:421-435. doi: 10.1200/CCI.19.00125. PMID: 32383980. PMC7265792.
  3. Liu A, Ferretti C, Shi FD, Cohen IR, Quintana FJ, La Cava A. DNA Vaccination With Hsp70 Protects Against Systemic Lupus Erythematosus in (NZB × NZW)F1 Mice. Arthritis Rheumatol. 2020 Jun;72(6):997-1002. doi: 10.1002/art.41202. PMID: 31943822.
  4. Morianos I, Trochoutsou AI, Papadopoulou G, Semitekolou M, Banos A, Konstantopoulos D, Manousopoulou A, Kapasa M, Wei P, Lomenick B, Belaidi E, Kalamatas T, Karageorgiou K, Doskas T, Sallusto F, Pan F, Garbis SD, Quintana FJ, Xanthou G. Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12269-12280. doi: 10.1073/pnas.1918196117. Erratum in: Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17447. PMID: 32409602. PMC7275751.
  5. Liu A, Shi FD, Cohen IR, Castaldo G, Matarese G, Quintana FJ, La Cava A. DNA vaccine encoding heat shock protein 90 protects from murine lupus. Arthritis Res Ther. 2020 Jun 22;22(1):152. doi: 10.1186/s13075-020-02246-4. PMID: 32571400. PMC7310240.
  6. Sádaba MC, Rothhammer V, Muñoz Ú, Sebal C, Escudero E, Kivisäkk P, Garcia Sanchez MI, Izquierdo G, Hauser SL, Baranzini SE, Oksenberg JR, Álvarez-Lafuente R, Bakshi R, Weiner HL, Quintana FJ. Serum antibodies to phosphatidylcholine in MS. Neurol Neuroimmunol Neuroinflamm. 2020 Jun 9;7(4):e765. doi: 10.1212/NXI.0000000000000765. PMID: 32518205. PMC7309529.
  7. Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VK. Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. Cell Rep. 2020 Jul 14;32(2):107892. doi: 10.1016/j.celrep.2020.107892. PMID: 32668241. PMC7496220.
  8. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Aug;23(8):939-951. doi: 10.1038/s41593-020-0664-0. Erratum in: Nat Neurosci. 2020 Oct;23(10):1307. PMID: 32690969. PMC7897397.
  9. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 Oct;586(7829):417-423. doi: 10.1038/s41586-020-2777-8. PMID: 32999463. PMC7577179.
  10. Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR. Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger. Anal Chem. 2020 Nov 3;92(21):14616-14623. doi: 10.1021/acs.analchem.0c03059. PMID: 33049138. PMC8182774.
  11. Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA. From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function. Am J Physiol Cell Physiol. 2020 Dec 1;319(6):C997-C1010. doi: 10.1152/ajpcell.00392.2020. PMID: 32991210. PMC7792679.
  12. Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK. T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 Dec 15;205(12):3247-3262. doi: 10.4049/jimmunol.2000748. PMID: 33168576. PMC7725915.
  13. Kenison JE, Jhaveri A, Li Z, Khadse N, Tjon E, Tezza S, Nowakowska D, Plasencia A, Stanton VP Jr, Sherr DH, Quintana FJ. Tolerogenic nanoparticles suppress central nervous system inflammation. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32017-32028. doi: 10.1073/pnas.2016451117. PMID: 33239445. PMC7749362.
  14. Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2020 Dec 24;8(2):e933. doi: 10.1212/NXI.0000000000000933. PMID: 33361385. PMC7768947.

Reviews

  1. Antel JP, Becher B, Ludwin SK, Prat A, Quintana FJ. Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System. J Immunol. 2020 Jan 15;204(2):251-255. doi: 10.4049/jimmunol.1900908. PMID: 31907266.
  2. Kadowaki A, Quintana FJ. The NLRP3 inflammasome in progressive multiple sclerosis. Brain. 2020 May 1;143(5):1286-1288. doi: 10.1093/brain/awaa135. PMID: 32438410. PMC7241945.
  3. Gabriely G, Quintana FJ. Role of AHR in the control of GBM-associated myeloid cells. Semin Cancer Biol. 2020 Aug;64:13-18. doi: 10.1016/j.semcancer.2019.05.014. PMID: 31128300. PMC6874737.
  4. Kadowaki A, Quintana FJ. The Gut-CNS Axis in Multiple Sclerosis. Trends Neurosci. 2020 Aug;43(8):622-634. doi: 10.1016/j.tins.2020.06.002. PMID: 32650957. PMC8284847.
  5. Giovannoni F, Quintana FJ. The Role of Astrocytes in CNS Inflammation. Trends Immunol. 2020 Sep;41(9):805-819. doi: 10.1016/j.it.2020.07.007. PMID: 32800705. PMC8284746.
  6. Probert L, Quintana FJ, Bar-Or A. Editorial: Update on Translational Neuroimmunology – Research of ISNI 2018. Front Immunol. 2020 Sep 30;11:2012. doi: 10.3389/fimmu.2020.02012. PMID: 33101268. PMC7554330.
  7. Linnerbauer M, Wheeler MA, Quintana FJ. Astrocyte Crosstalk in CNS Inflammation. Neuron. 2020 Nov 25;108(4):608-622. doi: 10.1016/j.neuron.2020.08.012. PMID: 32898475. PMC7704785.

2019

Articles

  1. Starossom SC, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F, Infante-Duarte C, Khoury SJ. Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation. Nat Commun. 2019 Jan 15;10(1):217. doi: 10.1038/s41467-018-08140-7. PMID: 30644388. PMC6333780.
  2. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. PMID: 30661753. PMC6440749.
  3. Hemond CC, Healy BC, Tauhid S, Mazzola MA, Quintana FJ, Gandhi R, Weiner HL, Bakshi R. MRI phenotypes in MS: Longitudinal changes and miRNA signatures. Neurol Neuroimmunol Neuroinflamm. 2019 Feb 14;6(2):e530. doi: 10.1212/NXI.0000000000000530. PMID: 30800720. PMC6384020.
  4. Ambrosio LF, Insfran C, Volpini X, Acosta Rodriguez E, Serra HM, Quintana FJ, Cervi L, Motrán CC. Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection. Front Immunol. 2019 Mar 29;10:631. doi: 10.3389/fimmu.2019.00631. PMID: 30984194. PMC6450169.
  5. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 May;22(5):729-740. doi: 10.1038/s41593-019-0370-y. Erratum in: Nat Neurosci. 2019 Sep;22(9):1533. PMID: 30962630. PMC8052632.
  6. Araujo LP, Maricato JT, Guereschi MG, Takenaka MC, Nascimento VM, de Melo FM, Quintana FJ, Brum PC, Basso AS. The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells. Cell Rep. 2019 Sep 17;28(12):3120-3130.e5. doi: 10.1016/j.celrep.2019.08.042. PMID: 31533035.
  7. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j.cell.2019.11.016. PMID: 31813625. PMC6936326.

Reviews

  1. Quintana FJ. Astrocytes play a crucial role in the formation and evolution of MS lesions – Commentary. Mult Scler. 2019 Jan;25(1):19-20. doi: 10.1177/1352458518796693. PMID: 30136890. PMC6387646.
  2. Wheeler MA, Quintana FJ. Regulation of Astrocyte Functions in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):a029009. doi: 10.1101/cshperspect.a029009. PMID: 29358321. PMC6314073.
  3. Quintana FJ. Myeloid cells in the central nervous system: So similar, yet so different. Sci Immunol. 2019 Feb 8;4(32):eaaw2841. doi: 10.1126/sciimmunol.aaw2841. PMID: 30737356.
  4. Rothhammer V, Quintana FJ. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol. 2019 Mar;19(3):184-197. doi: 10.1038/s41577-019-0125-8. PMID: 30718831.
  5. Sanmarco LM, Quintana FJ. Meningeal Memories of Viral Infection. Trends Neurosci. 2019 Aug;42(8):513-514. doi: 10.1016/j.tins.2019.06.001. PMID: 31253444.
  6. Gabriely G, Quintana FJ. Role of AHR in the control of GBM-associated myeloid cells. Semin Cancer Biol. 2020 Aug;64:13-18. doi: 10.1016/j.semcancer.2019.05.014. PMID: 31128300. PMC6874737.

2018

Articles

  1. Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM. Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6. J Neurochem. 2018 Jan;144(2):128-138. doi: 10.1111/jnc.14243. PMID: 29049850.
  2. Dolciami D, Gargaro M, Cerra B, Scalisi G, Bagnoli L, Servillo G, Fazia MAD, Puccetti P, Quintana FJ, Fallarino F, Macchiarulo A. Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist. ChemMedChem. 2018 Feb 6;13(3):270-279. doi: 10.1002/cmdc.201700669. PMID: 29266750.
  3. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep. 2018 Mar 21;8(1):4970. doi: 10.1038/s41598-018-23323-4. PMID: 29563571. PMC5862868.
  4. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 May;557(7707):724-728. doi: 10.1038/s41586-018-0119-x. PMID: 29769726. PMC6422159.
  5. Dossi DE, Chaves H, Heck ES, Rodriguez Murúa S, Ventrice F, Bakshi R, Quintana FJ, Correale J, Farez MF. Effects of Systolic Blood Pressure on Brain Integrity in Multiple Sclerosis. Front Neurol. 2018 Jun 25;9:487. doi: 10.3389/fneur.2018.00487. PMID: 29988562. PMC6026666.
  6. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn’s disease. J Autoimmun. 2018 Nov;94:122-133. doi: 10.1016/j.jaut.2018.07.022. PMID: 30098863. PMC6193817.

Reviews

  1. Gutiérrez-Vázquez C, Quintana FJ. Regulation of the Immune Response by the Aryl Hydrocarbon Receptor. Immunity. 2018 Jan 16;48(1):19-33. doi: 10.1016/j.immuni.2017.12.012. PMID: 29343438. PMC5777317.

2017

Articles

  1. Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL. Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun. 2017 Jan;76:115-122. doi: 10.1016/j.jaut.2016.10.001. PMID: 27745778. PMC9815832.
  2. Rothhammer V, Kenison JE, Tjon E, Takenaka MC, de Lima KA, Borucki DM, Chao CC, Wilz A, Blain M, Healy L, Antel J, Quintana FJ. Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2012-2017. doi: 10.1073/pnas.1615413114. PMID: 28167760. PMC5338419.
  3. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 4;2(9):e92791. doi: 10.1172/jci.insight.92791. PMID: 28469075. PMC5414551.
  4. Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N. IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017 Jun 29;170(1):127-141.e15. doi: 10.1016/j.cell.2017.06.016. PMID: 28666115. PMC5569303.
  5. Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivisäkk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ. Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jun 16;4(4):e359. doi: 10.1212/NXI.0000000000000359. PMID: 28642887. PMC5473958.
  6. Kim G, Chu R, Yousuf F, Tauhid S, Stazzone L, Houtchens MK, Stankiewicz JM, Severson C, Kimbrough D, Quintana FJ, Chitnis T, Weiner HL, Healy BC, Bakshi R. Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis. Int J Neurosci. 2017 Nov;127(11):971-980. doi: 10.1080/00207454.2017.1283313. PMID: 28100092.

Reviews

  1. Takenaka MC, Quintana FJ. Tolerogenic dendritic cells. Semin Immunopathol. 2017 Feb;39(2):113-120. doi: 10.1007/s00281-016-0587-8. PMID: 27646959. PMC5296314.
  2. Quintana FJ. Dendritic cells in autoimmunity, infections, and cancer. Semin Immunopathol. 2017 Feb;39(2):97-98. doi: 10.1007/s00281-016-0618-5. PMID: 28093619. PMC5296286.
  3. Gabriely G, Wheeler MA, Takenaka MC, Quintana FJ. Role of AHR and HIF-1α in Glioblastoma Metabolism. Trends Endocrinol Metab. 2017 Jun;28(6):428-436. doi: 10.1016/j.tem.2017.02.009. PMID: 28318896. PMC5438779.
  4. Wheeler MA, Rothhammer V, Quintana FJ. Control of immune-mediated pathology via the aryl hydrocarbon receptor. J Biol Chem. 2017 Jul 28;292(30):12383-12389. doi: 10.1074/jbc.R116.767723. PMID: 28615443. PMC5535014.
  5. Quintana FJ. Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation. J Clin Invest. 2017 Aug 1;127(8):2897-2899. doi: 10.1172/JCI95769. PMID: 28737511. PMC5531401.
  6. Quintana FJ, Prinz M. A gut feeling about multiple sclerosis. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10528-10529. doi: 10.1073/pnas.1714260114. PMID: 28973867. PMC5635933.

2016

Articles

  1. Takenaka MC, Araujo LP, Maricato JT, Nascimento VM, Guereschi MG, Rezende RM, Quintana FJ, Basso AS. Norepinephrine Controls Effector T Cell Differentiation through β2-Adrenergic Receptor-Mediated Inhibition of NF-κB and AP-1 in Dendritic Cells. J Immunol. 2016 Jan 15;196(2):637-44. doi: 10.4049/jimmunol.1501206. PMID: 26663782.
  2. Covacu R, Philip H, Jaronen M, Almeida J, Kenison JE, Darko S, Chao CC, Yaari G, Louzoun Y, Carmel L, Douek DC, Efroni S, Quintana FJ. System-wide Analysis of the T Cell Response. Cell Rep. 2016 Mar 22;14(11):2733-44. doi: 10.1016/j.celrep.2016.02.056. PMID: 26972015. PMC4805488.
  3. Bakshi R, Yeste A, Patel B, Tauhid S, Tummala S, Rahbari R, Chu R, Regev K, Kivisäkk P, Weiner HL, Quintana FJ. Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(2):e200. doi: 10.1212/NXI.0000000000000200. PMID: 26894204. PMC4747479.
  4. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016 Jun;22(6):586-97. doi: 10.1038/nm.4106. PMID: 27158906. PMC4899206.
  5. Fernández D, Flores-Santibáñez F, Neira J, Osorio-Barrios F, Tejón G, Nuñez S, Hidalgo Y, Fuenzalida MJ, Meza D, Ureta G, Lladser A, Pacheco R, Acuña-Castillo C, Guixé V, Quintana FJ, Bono MR, Rosemblatt M, Sauma D. Purinergic Signaling as a Regulator of Th17 Cell Plasticity. PLoS One. 2016 Jun 20;11(6):e0157889. doi: 10.1371/journal.pone.0157889. PMID: 27322617. PMC4913941.
  6. Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016 Jun 21;9(433):ra61. doi: 10.1126/scisignal.aad0612. PMID: 27330188.
  7. Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015. PMID: 27352007. PMC4931233.
  8. Sisirak V, Sally B, D’Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçınkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30;166(1):88-101. doi: 10.1016/j.cell.2016.05.034. PMID: 27293190. PMC5030815.
  9. Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 Jul;139(Pt 7):1939-57. doi: 10.1093/brain/aww113. PMID: 27246324. PMC4939696.
  10. Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 Oct 25;17(5):1318-1329. doi: 10.1016/j.celrep.2016.09.082. PMID: 27783946. PMC5106873.
  11. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 Dec;151(6):1100-1104. doi: 10.1053/j.gastro.2016.08.055. PMID: 27693323. PMC5124405.

Reviews

  1. Caballero-Hernandez D, Toscano MG, Cejudo-Guillen M, Garcia-Martin ML, Lopez S, Franco JM, Quintana FJ, Roodveldt C, Pozo D. The ‘Omics’ of Amyotrophic Lateral Sclerosis. Trends Mol Med. 2016 Jan;22(1):53-67. doi: 10.1016/j.molmed.2015.11.001. PMID: 26691296.
  2. Takenaka MC, Quintana FJ. Achieving Tolerance with Perforin-Secreting Dendritic Cells. Trends Mol Med. 2016 Jan;22(1):3-4. doi: 10.1016/j.molmed.2015.11.008. PMID: 26700492. PMC4707090.
  3. Quintana FJ, VanHook AM. Science Signaling Podcast for 21 June 2016: Nanoparticles to treat type 1 diabetes. Sci Signal. 2016 Jun 21;9(433):c15. doi: 10.1126/scisignal.aag2900. PMID: 27330187.
  4. Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Immunol. 2016 Jul;37(7):427-439. doi: 10.1016/j.it.2016.04.009. PMID: 27236363. PMC5215082.
  5. Poutiainen P, Jaronen M, Quintana FJ, Brownell AL. Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci. 2016 Sep 15;9:85. doi: 10.3389/fnmol.2016.00085. PMID: 27695400;. PMC5023680.
  6. Farez MF, Calandri IL, Correale J, Quintana FJ. Anti-inflammatory effects of melatonin in multiple sclerosis. Bioessays. 2016 Oct;38(10):1016-26. doi: 10.1002/bies.201600018. PMID: 27561251.
  7. Rothhammer V, Quintana FJ. Environmental control of autoimmune inflammation in the central nervous system. Curr Opin Immunol. 2016 Dec;43:46-53. doi: 10.1016/j.coi.2016.09.002. PMID: 27710839. PMC5125858.
  8. Quintana FJ. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol. 2016 Dec 16;18(1):8-10. doi: 10.1038/ni.3637. PMID: 27984572.

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