Publications

Full List of Publications in PubMed
Representative Publications
  1. Kenison JE, Jhaveri A, Li Z, Khadse N, Tjon E, Tezza S, Nowakowska D, Plasencia A, Stanton VP Jr, Sherr DH, Quintana FJ. Tolerogenic nanoparticles suppress central nervous system inflammation. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32017-28. PMID: 33239445. PMC7749362.
  2. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Aug;23(8):939-51. Erratum in: Nat Neurosci. 2020 Oct;23(10):1307. PMID: 32690969. PMC7897397.
  3. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 Feb;578(7796):593-9. PMID: 32051591. PMC8039910.
  4. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 Dec 12;179(7):1483-98.e22. PMID: 31813625; PMCID: PMC6936326.
  5. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 May;22(5):729-40. Erratum in: Nat Neurosci. 2019 Sep;22(9):1533. PMID: 30962630. PMC8052632.
  6. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019 Jan 24;176(3):581-96. PMID: 30661753. PMC6440749.
  7. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 May;557(7707):724-8. PMID: 29769726. PMC6422159.
  8. Rothhammer V, Kenison JE, Tjon E, Takenaka MC, de Lima KA, Borucki DM, Chao CC, Wilz A, Blain M, Healy L, Antel J, Quintana FJ. Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2012-7. PMID: 28167760. PMC5338419.
  9. Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016 Jun 21;9(433):ra61. PMID: 27330188.
  10. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016 Jun;22(6):586-97. PMID: 27158906. PMC4899206.
  11. Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10;162(6):1338-52. PMID: 26359987. PMC4570563.
  12. Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Nat Med. 2015 Jun;21(6):638-46. PMID: 26005855. PMC4476246.
  13. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. PMID: 25216636. PMC4255949.
  14. Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct;14(10):1054-63. PMID: 23995234. PMC3964005.
  15. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012 Jul 1;13(8):770-7. Erratum in: Nat Immunol. 2014 Jan;15(1):109. PMID: 22751139. PMC3541018.
  16. Yeste A, Nadeau M, Burns EJ, Weiner HL, Quintana FJ. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11270-5. PMID: 22745170. PMC3396465.
  17. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep;11(9):854-61. PMID: 20676095. PMC2940320.
  18. Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010 Sep;11(9):846-53. PMID: 20676092. PMC2929008.
  19. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008 May 1;453(7191):65-71. PMID: 18362915.

 

—

Publications by year:

2021

Articles

  1. Giovannoni F*, Li Z*, Remes-Lenicov F, Dávola ME, Elizalde M, Paletta A, Ashkar AA, Mossman KL, Dugour AV, Figueroa JM, Barquero AA, Ceballos A, Garcia CC, Quintana FJ. AHR signaling is induced by infection with coronaviruses. Nat Commun. 2021 Aug;12:5148. PMID: 34446714.
  2. Scott BM*, Gutiérrez-Vázquez C*, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A, Hewson P, Cox LM, O’Brien M, Chen SK, Moraes-Vieira PM, Chang BSW, Peisajovich SG, Quintana FJ. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021 Jul;27(7):1212-1222. PMID: 34183837
  3. Friedrich M*, Sankowski R*, Bunse L*, Kilian M, Green E, Ramallo Guevara C, Pusch S, Poschet G, Sanghvi K, Hahn M, Bunse T, Münch P, Gegner HM, Sonner JK, von Landenberg Anna, Cichon F, Aslan K, Trobisch T, Schirmer L, Abu-Sammour D, Kessler T, Ratliff M, Schrimpf D, Sahm F, Hopf C, Heiland DH, Schnell O, Beck J, Böttcher C, Fernandez-Zapata C, Priller J, Heiland S, Gutcher I, Quintana FJ, von Deimling A, Wick W, Prinz M*, Platten M*. Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas. Nat Cancer. 2021 Jul;2, 723–740. DOI: 10.1038/s43018-021-00201-z
  4. Kenison JE, Wang Z, Yang K, Snyder M, Quintana FJ, Sherr DH. The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation. Proceedings of the National Academy of Sciences. May 11, 2021 118 (19) e2012692118. DOI: 10.1073/pnas.2012692118
  5. Levy O*, Rothhammer V*, Mascanfroni I*, Tong Z, Kuai R, De Biasio M, Wang Q, Majid T, Perrault C, Yeste A, Kenison JE, Safaee H, Musabeyezu J, Heinelt M, Milton Y, Kuang H, Lan H, Siders W, Multon MC, Rothblatt J, Massadeh S, Alaamery M, Alhasan AH, Quintana FJ, Karp JM. A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 May;99(5):663-671. PMID: 33398468.

  6. Clark IC*, Gutiérrez-Vázquez C*, Wheeler MA*, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Polonio CM, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, de Lima KA, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 Apr 23;372(6540):eabf1230. PMID: 33888612. PMC8157482

  7. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proceedings of the National Academy of Sciences. 2021 March 118 (12) e2017719118. DOI: 10.1073/pnas.2017719118
  8. Rothhammer V, Kenison JE, Li Z, Tjon E, Takenaka MC, Chao CC, de Lima KA, Borucki DM, Kaye J, Quintana FJ. Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS. Neurol Neuroimmunol Neuroinflamm. Mar 2021, 8 (2) e946. DOI: 10.1212/NXI.0000000000000946
  9. Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm Mar 2021, 8 (2) e933; DOI: 10.1212/NXI.0000000000000933

  10. Sanmarco LM*, Wheeler MA*, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes. Nature. 2021 Feb;590(7846):473-9.  PMID: 33408417. PMC8039910.

Reviews

  1. Andersen BM*, Faust Akl C*, Wheeler MA, Chiocca EA, Reardon DA, Quintana FJ. Glial and myeloid heterogeneity in the brain tumour microenvironment. Nat Rev Cancer. 2021 Sep 28 (in press). PMID: 34584243.
  2. Tuzlak S*, Dejean AS, Iannacone M, Quintana FJ, Waisman A, Ginhoux F*, Korn T*, Becher B*. Repositioning T H cell polarization from single cytokines to complex help. Nat Immunol . 2021 Oct;22(10):1210-1217. PMID: 34545250.
  3. Sanmarco LM*, Polonio CM*, Wheeler MA*, Quintana FJ. Functional immune cell-astrocyte interactions. J Exp Med. 2021 Sep 6;218(9):e20202715. PMID: 34292315
  4. Alaamery M, Albesher N, Aljawini N, Alsuwailm M, Massadeh S, Wheeler MA, Chao CC, Quintana FJ. Role of sphingolipid metabolism in neurodegeneration. J Neurochem. 2021 Jul;158(1):25-35. PMID: 32402091.
  5. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling. Curr Opin Immunol. 2021 Jun;70:33-39. PMID: 33607496.
  6. Prinz M, Masuda T, Wheeler MA, Quintana FJ. Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. Annu Rev Immunol. 2021 Apr 26;39:251-277. PMID: 33556248.
  7. Torti MF*, Giovannoni F*, FJ Quintana†, García CC†. The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity. Front Immunol. 2021 Mar 5;12:624293. PMID: 33746961.
  8. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. The aryl hydrocarbon receptor and the gut-brain axis. Cell Mol Immunol. 2021 Feb;18(2):259-268. PMID: 33408340.

 

2022

Articles

  1. Quintana FJ, Pozo D. Editorial: Nanoparticle-Mediated Signaling Rewiring and Reprogramming of Immune Responses. Front Immunol. 2022 May 12;13:927733. PMID: 35634330.
  2. Couturier CP, Nadaf J, Li Z, Baig S, Riva G, Le P, Kloosterman DJ, Monlong J, Nkili Meyong A, Allache R, Degenhard T, Al-Rashid M, Guiot MC, Bourque G, Ragoussis J, Akkari L, Quintana FJ, Petrecca K. Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells. Neuro Oncol. 2022 Apr 13. PMID: 35416251.
  3. Linnerbauer M, Lößlein L, Vandrey O, Tsaktanis T, Beer A, Naumann UJ, Panier F, Beyer T, Nirschl L, Kuramatsu JB, Winkler J, Quintana FJ, Rothhammer V. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation. JCI Insight. 2022 Apr 8;7(7):e154824. PMID: 35393953.
  4. Jaronen M, Wheeler MA, Quintana FJ. Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish. STAR Protoc. 2022 Jan 28;3(1):101134. PMID: 35128477.
  5. Sanmarco LM, Chao CC, Wang YC, Kenison JE, Li Z, Rone JM, Rejano-Gordillo CM, Polonio CM, Gutierrez-Vazquez C, Piester G, Plasencia A, Li L, Giovannoni F, Lee HG, Faust Akl C, Wheeler MA, Mascanfroni I, Jaronen M, Alsuwailm M, Hewson P, Yeste A, Andersen BM, Franks DG, Huang CJ, Ekwudo M, Tjon EC, Rothhammer V, Takenaka M, de Lima KA, Linnerbauer M, Guo L, Covacu R, Queva H, Fonseca-Castro PH, Bladi MA, Cox LM, Hodgetts KJ, Hahn ME, Mildner A, Korzenik J, Hauser R, Snapper SB, Quintana FJ. Identification of environmental factors that promote intestinal inflammation. Nature. 2022 Nov;611(7937):801-809. doi: 10.1038/s41586-022-05308-6. Epub 2022 Oct 20. PMID: 36266581; PMCID: PMC9898826.
  6. Charabati M, Grasmuck C, Ghannam S, Bourbonnière L, Fournier AP, Lécuyer MA, Tastet O, Kebir H, Rébillard RM, Hoornaert C, Gowing E, Larouche S, Fortin O, Pittet C, Filali-Mouhim A, Lahav B, Moumdjian R, Bouthillier A, Girard M, Duquette P, Cayrol R, Peelen E, Quintana FJ, Antel JP, Flügel A, Larochelle C, Arbour N, Zandee S, Prat A. DICAM promotes TH17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation. Sci Transl Med. 2022 Jan 5;14(626):eabj0473. doi: 10.1126/scitranslmed.abj0473. Epub 2022 Jan 5. PMID: 34985970.
  7. Yu Y, Yang W, Yu T, Zhao X, Zhou Z, Yu Y, Xiong L, Yang H, Bilotta AJ, Yao S, Golovko G, Plasencia A, Quintana FJ, Zhou L, Li Y, Cong Y. Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis. iScience. 2022 Aug 24;25(9):105004. doi: 10.1016/j.isci.2022.105004. PMID: 36093065; PMCID: PMC9460814.
  8. Alaamery M, Alghamdi J, Massadeh S, Alsawaji M, Aljawini N, Albesher N, Alghamdi B, Almutairi M, Hejaili F, Alfadhel M, Baz B, Almuzzaini B, Almutairi AF, Abdullah M, Quintana FJ, Sayyari A. Analysis of chronic kidney disease patients by targeted next-generation sequencing identifies novel variants in kidney-related genes. Front Genet. 2022 Aug 11;13:886038. doi: 10.3389/fgene.2022.886038. PMID: 36035137; PMCID: PMC9407681.
  9. Muñoz Ú, Sebal C, Escudero E, Urcelay E, Arroyo R, García-Martínez MA, Quintana FJ, Álvarez-Lafuente R, Sádaba MC. Serum levels of IgM to phosphatidylcholine predict the response of multiple sclerosis patients to natalizumab or IFN-β. Sci Rep. 2022 Aug 3;12(1):13357. doi: 10.1038/s41598-022-16218-y. PMID: 35922641; PMCID: PMC9349316.

Reviews

  1. Olude MA, Mouihate A, Mustapha OA, Farina C, Quintana FJ, Olopade JO. Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective. Front Immunol. 2022 May 30;13:795089. PMID: 35707531.
  2. Lee HG, Wheeler MA, Quintana FJ. Function and therapeutic value of astrocytes in neurological diseases. Nat Rev Drug Discov. 2022 May;21(5):339-358. PMID: 35173313.
  3. Andersen, B.M., Quintana, F.J. Neuro-immune crosstalk in drug-resistant epilepsy. Nat Neurosci (2022). PMID: 35739272
  4. Rodríguez Murúa S, Farez MF, Quintana FJ. The Immune Response in Multiple Sclerosis. Annu Rev Pathol. 2022 Jan 24;17:121-139. doi: 10.1146/annurev-pathol-052920-040318. Epub 2021 Oct 4. PMID: 34606377.

2023

Articles

  1. Wheeler MA*, Clark IC*, Lee HG*, Li Z, Linnerbauer M, Rone JM, Blain M, Akl CF, Piester G, Giovannoni F, Charabati M, Lee JH, Kye YC, Choi J, Sanmarco LM, Srun L, Chung EN, Flausino LE, Andersen BM, Rothhammer V, Yano H, Illouz T, Zandee SEJ, Daniel C, Artis D, Prinz M, Abate AR, Kuchroo VK, Antel JP, Prat A, Quintana FJ. Droplet-based forward genetic screening of astrocyte-microglia cross-talk. Science. 2023 Mar 10;379(6636):1023-1030. doi: 10.1126/science.abq4822. Epub 2023 Mar 9. PMID: 36893254.
  2. Clark IC*, Wheeler MA*, Lee HG, Li Z, Sanmarco LM, Thaploo S, Polonio CM, Shin SW, Scalisi G, Henry AR, Rone JM, Giovannoni F, Charabati M, Akl CF, Aleman DM, Zandee SEJ, Prat A, Douek DC, Boritz EA, Quintana FJ, Abate AR. Identification of astrocyte regulators by nucleic acid cytometry. Nature. 2023 Feb;614(7947):326-333. doi: 10.1038/s41586-022-05613-0. Epub 2023 Jan 4. PMID: 36599367; PMCID: PMC9980163.
  3. Clark IC, Mudvari P, Thaploo S, Smith S, Abu-Laban M, Hamouda M, Theberge M, Shah S, Ko SH, Pérez L, Bunis DG, Lee JS, Kilam D, Zakaria S, Choi S, Darko S, Henry AR, Wheeler MA, Hoh R, Butrus S, Deeks SG, Quintana FJ, Douek DC, Abate AR*, Boritz EA*. HIV silencing and cell survival signatures in infected T cell reservoirs. Nature. 2023 Feb;614(7947):318-325. doi: 10.1038/s41586-022-05556-6. Epub 2023 Jan 4. PMID: 36599978; PMCID: PMC9908556.
Back To Top